Abstract
Summary
Administration of parathyroid hormone to guinea pigs caused a consistent significant decrease in the femoral concentration of calcium, but no change in concentration of collagen (measured as hydroxyproline), DNA, or polysaccharide (measured as uronic acid). A small but not significant decrease in bone hexosamine concentration occurred. These data indicate that mineral can be mobilized from bone without a concomitant decrease in concentration of matrix constituents.
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