Effects of Epsilon-Amino-Caproic Acid on Prolactin-Inactivating and Fibrinolytic Activities of Streptokinase-Activated Plasminogen. ∗

Abstract

Summary

Ovine prolactin (0.5 mg) was incubated for 2 hours at 37.5°C with human plasminogen with and without e-aminocaproic acid (EACA). Fibrinolytic activity (FA) and prolactin-inactivating activity (PIA) were increased by streptokinase (SK). EACA at 0.026 M (5.0 mg) and 0.26 M (50.0 mg) increased FA but did not increase PIA. Antifibrinolysin (100 U) completely inhibited both activities.