Abstract
Summary
The antipyretic effects of salicylic acid and of a structurally related compound, the dye aurintricarboxylic acid (ATA), were compared in rats with fevers induced by subcutaneous injection of yeast. The two compounds had comparable effects on fever and, when injected together, their effects were additive. ATA had a more transient effect, reduced the temperature of rats without fevers, and reduced fevers by a specific amount rather than to a specific temperature as did salicylate. These differences led to the postu-lation of a direct peripheral action of ATA.
Get full access to this article
View all access options for this article.