Abstract
Summary
Administration of 1–3 mg of PA subcutaneously to normal rats at intervals of 1–2 weeks produced significant proteinuria after a prolonged latent period provided the total dose exceeded a threshold dose of approximately 4–5 mg. Analysis of the cumulative dose-response curves revealed that doses administered subcutaneously at biweekly intervals were more effective in producing proteinuria than the same total dose given on a daily or weekly schedule. While the mechanism of PA nephrotoxicity is still not known, it is unlikely that it acts by direct enzyme inhibition.
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