Abstract
Summary
Urinary excretion ratios of meprobamate and its major metabolic product, hydroxymeprobamate, were determined in a number of laboratory animal species following administration of meprobamate by several routes. No major differences were apparent. Humans receiving relatively small doses of this drug excreted a higher proportion of unchanged meprobamate, especially after a single administration of the drug. Chronic administration of meprobamate to humans appeared to stimulate its metabolism.
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