Abstract
Summary
The release of catecholamines produced by tyramine in the isolated cat heart is inhibited by phenoxybenzamine and GD-131 but not by phentolamine or dihydroergotamine. Inhibition of the release of catecholamines is associated with a marked reduction in the positive inotropic effect of tyramine. The possibility is suggested that β-haloalkylamines may interfere with the release of catecholamines in vivo as well as inhibiting the effects of catecholamines on effector cells.
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