Abstract
Summary
The susceptibility of oxytocin and desamino-oxytocin to attack by hog kidney leucine aminopeptidase and α-chymotrypsin has been investigated by measurement of their avian depressor activity before and after incubation with the enzymes. On this basis desamino-oxytocin appeared to be resistant to the action of leucine aminopeptidase whereas 50% of the activity of oxytocin was lost after treatment with the enzyme. On the other hand, desamino-oxytocin was found to be completely inactivated by α-chymotrypsin under conditions in which some of the activity of oxytocin still remained.
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