Abstract
Summary
Host and donor pigeons made immunologically tolerant in various combinations by skin grafting shortly after hatching were exposed to lethal doses of irradiation at the age of 8–10 months. Homologous bone marrow transplants gave the following results:
1) The tolerant state of the host did not appreciably affect survival; i.e., mean survival of Group 1 (host tolerant of donor) was 23.4 ± 5.6 and of Group 4 (no known tolerance) was 25.3 ± 4.1 days.
2) Tolerance of marrow donors for host increased mean survival by about 10 days (34.2 ± 4.3 for Group 2 and 35.6 ± 5.2 for Group 3). Differences in mean survival between combined Groups 1, 4 and 2, 3 were statistically significant (p<.05).
3) These data suggest that the immunologic mechanism of the donor is more important than that of the host in producing “homologous disease” in the pigeon.
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