Abstract
Summary
The effect of treatment with hydrocortisone upon growth and maturation of the silicotic nodule has been studied in mouse liver. Treatment slowed growth of lesions and development of collagen and reticulin regardless of the time at which therapy was instituted. When hydrocortisone was discontinued, however, the size of nodules returned close to control level. Histological differences were noted between control and treated nodules after 150 days. These differences (disorganization and cellularity of treated nodules) suggest a continuation of the early inflammatory response in hydrocortisone treated lesions.
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