Abstract
Summary
(1) Three sheep developed a fatal nephritis in 45 to 54 days when immunized with heterologous GBM and Freund's adjuvant in the last third of their pregnancy. (2) Immunization of the mothers or suckling their colustrum (in 2 of the 4 lambs) did not produce a renal lesion in the lambs. (3) It appears that the agent which produces a fatal nephritis in the mother was either not transmitted in utero or in the colustrum or it was incapable of affecting the fetal or neonatal kidney. (4) The above observations are consistent with the hypothesis that this sheep nephritis is produced by an autoimmune mechanism mediated by sensitized cells and/or autoantibody.
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