Abstract
Summary
These investigations reemphasize the utility of the isolated rat liver perfusion system for studying metabolic activity. The data obtained show that livers from azo-dye fed rats have an enhanced capacity for synthesis of acid-soluble liver proteins. These findings suggest further that 5-bis-(2 chloroethyl)-aminouracil is capable of inhibiting acid-soluble liver protein synthesis in liver of normal rats or in livers undergoing azo-dye carcinogenesis.
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