Influence of Age and N,N'-Diethylene-N”-Phenethylphosphoramide (PEDP)Upon Nucleic Acid and Ribonuclease Activity in Tumor Tissue. ∗

Abstract

Summary

As the Walker 256 tumor increased in size and approached maximum development, the ribonuclease activity per gram of tumor or per mg of deoxyribonucleic acid phosphorus (DNA-P) also increased. The slower growing, larger tumor had a markedly decreased ribonucleic acid phosphorus (RNA-P) and protein concentration. Treating the tumor-bearing rat with N, N'-diethylene-N”-phenethylphosphoramide (PEDP) resulted in reduced rate of growth of the tumor, increased ribonuclease activity, and decreased RNA-P.