Abstract
Summary
The relationship of renal erythropoietin to the juxtaglomerular cell was studied. Several investigators have noted the frequent association of increased juxtaglomerular granularity and increased levels of plasma erythropoietin after the combined stimuli of underdistention of the renal arterial bed and hypoxia of the renal parenchyma. To separate these two stimuli, rats were subjected to hypoxia without hypovolemia by being kept at one-half atmospheric pressure for 12 hours. At the end of the hypoxic period, there was no change in the granularity of the juxtaglomerular cells and, therefore, probably no change in their rate of secretion. Two hypotheses concerning the cellular source of renal erythropoietin are presented.
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