Effect of Phenylalanine on Toxicity of S-(Dichlorovinyl)-L-Cysteine in the Rat and the Calf. ∗

Abstract

Summary

Both enantiomers of phenylalanine when injected intraperitoneally into rats can greatly reduce the toxicity of S-(1,2-dichlorovinyl)-L-cysteine. To be most effective the DCVC and Phe must be administered simultaneously, a delay of one hour in injection of phenylalanine reducing its effectiveness markedly. Administration of L-phenylalanine to calves failed to reduce the toxic effects of S-(dichlorovinyl)-L-cysteine and development of fatal aplastic anemia.