Abstract
Summary
Unsaturated fatty acids in the diet exert a profound influence on the level of alkaline phosphatase in the plasma of rats with biliary obstruction as well as in normal rats. Following ligation of the common bile duct, alkaline phosphatase was increased about 3-fold in rats fed a diet containing oleic acid. No rise of alkaline phosphatase occurred after biliary obstruction in rats fed the same diet containing no unsaturated fatty acids. Rise in plasma bilirubin occurred after ligation of the common duct regardless of the content or composition of fatty acids in the diet. In the dog with ligation of the bile duct no relation was detected between unsaturated fatty acids in the diet and the increased (about 60-fold) alkaline phosphatase of the plasma; the enzyme rose to very high and nearly similar levels in dogs fed diets with or without unsaturated fatty acids after ligation of the common bile duct.
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