Abstract
Summary
Encephalitogenic emulsion was widely disseminated in superficial and retroperitoneal lymph nodes following inoculation into the foot pad of rats. Therefore, it was not possible to prevent experimental allergic encephalomyelitis (EAE) by removing only popliteal and inguinal nodes. In contrast, dissemination was more restricted following flank inoculation so that EAE was prevented by homolateral or bilateral excision of axillary, inguinal and elbow nodes, either on day of challenge or 7 days later. Interruption of lymphatic vessels during surgery near lymph nodes (as in “sham” operations), the stressful effects of surgery, and the redistribution of emulsion following elimination of customary drainage pathways were also found to affect experiments designed to influence EAE by lymphadenectomy.
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