Abstract
Summary
Tissue cultured cells of certain mouse and hamster tumors were classified according to their reactions to polyoma virus. Group 1 cells had no morphologic changes and virus persisted only a few weeks in the culture. Murine RC carcinoma and ependymoma and HT6 fibrosarcoma (hamster) behaved in this way. Group 2 cells had variable degrees of cytolysis and morphologic changes; virus persisted for several weeks. L2 and 1210 lymphomas, 6C3HED lymphosarcoma (Gardner) and the P815 mast cell (Dunn-Potter) gave this response. Group 3 cells had no changes in cell morphology with persistent virus. A spontaneous adenocarcinoma (WT, Pearson) gave this response. Group 4 cells had cytolysis and virus persisted for months in surviving cells. The unclassified mouse tumor (WM, Pearson) reacted in this way.
Get full access to this article
View all access options for this article.