Regeneration of the Liver in Triturus viridescens. ∗

Abstract

Summary

Regeneration was studied in the liver of the newt, Triturus viridescens, following approximately 78% partial hepatectomy. H³-thymidine and autoradiographs were used to quantitate DNA synthesis in liver cell nuclei. DNA synthesis began 5 days after partial hepatectomy, reached a peak of 1.9% of liver cells at 10 days, fell to 0.2% at 20 days, rose to a second peak of 1.3% at 105 days, and continued at an elevated level of 0.5% at 150 days, the latest time studied. Liver weight was restored to normal 4 weeks after operation.