Abstract
Summary
Renal function studies were conducted in unanesthetized guinea pigs. 1. The mean value for inulin clearance obtained compares satisfactorily with published data in other small mammals. Inulin clearance is independent of plasma concentration over a wide range of U/P ratios and independent of urine flow except at very low flow rates, when it is depressed. 2. A ratio of endogenous creatinine to inulin clearances of 0.95 indicates that in the guinea pig, endogenous creatinine clearance is a measure of glomerular filtration rate. 3. The average ratio of urea to inulin clearance obtained here (0.61) agrees well with the established figure for most mammals. 4. Inulin and urea clearances were consistently reduced by prior administration of creatinine. The mechanism of this reduction is beyond the scope of this study. 5. The clearance of exogenous creatinine is greater than that of endogenous creatinine. This, with the foregoing, suggests that in this species there is a tubular component in excretion of exogenous creatinine.
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