Abstract
Summary
1. In mice, changes in dose in the sublethal range could be detected by means of lymphocyte counts 2 to 4 days after irradiation with an estimated accuracy of 66 rads, but as the dose was increased it soon became impossible to distinguish between doses by means of lymphocyte counts. 2. Changes in dose in the range 0 to LD95 could be detected by granulocyte counts 3 days after irradiation with an estimated accuracy of 145 rads and 4 days after irradiation, 107 rads. 3. Prior injection of endotoxin did not improve the accuracy of dose discrimination 3 days after irradiation. Four days after irradiation accuracy was increased in the higher dose range but usefulness of the procedure was limited by the acutely toxic effect of the endotoxin on lethally irradiated mice.
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