Abstract
Summary
1. A series of 7 groups of rats (12 per group) were studied using alternating subgroups of 6 each. Urine osmolality and papillary sodium concentration was determined after intravenous injection of saline and after saline plus pyrogen. 2. There was a highly significant fall in urine osmolality in rats which received saline plus pyrogen as compared to their saline controls. Similarly, renal papillae from rats which received pyrogen had a lower sodium concentration than the corresponding saline controls. 3. The data are best explained in terms of a counter current system relating the renal hyperemia of pyrogen administration to disruption of a counter-current diffusion exchanger.
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