Abstract
Summary
Epididymal adipose tissue was incubated with glycine-1-C14, glycine-2-C14, glyoxylate-1,2-C14, sarcosine-1-C14 and malate-1-C14; CO2 and fatty acids were isolated and analyzed for radioactivity. Glycine-1-C14 was converted to labeled fatty acids to a greater extent than glycine-2-C14. Radioactive acetate, propionate, glyoxylate and succinate were recovered as intermediate products of glycine metabolism. Addition of unlabeled acetate, propionate and glyoxylate reduced conversion of C14-glycine to fatty acids. Results show that glycine can be a precursor in the biosynthesis of fatty acids in adipose tissue. The path of conversion of glycine to fatty acids is discussed.
Get full access to this article
View all access options for this article.