Renal Effects of Renin in Normal and Buffer-Nerve Sectioned Dogs. ∗

Abstract

Summary

The effects of renin infusion were studied in anesthetized normal and buffer-nerve sectioned dogs during osmotic (mannitol) diuresis and hydropenia. Renin produced a rise in blood pressure and a decrease in C_PAH. These changes were more marked in buffer-nerve sectioned dogs. C_M fell by an average of 15% in 6 normal dogs in which urine and salt excretion also decreased. However, in another 4 normal dogs in which C_M remained unchanged during renin infusion, water and salt excretion increased moderately. In all the buffer-nerve sectioned dogs renin caused significant diuresis and natriuresis although C_M decreased slightly. The results show that buffer-nerve sectioned dogs are more sensitive than normal dogs to the diuretic action of renin. The possible mechanisms of this action have been discussed.