Abstract
Summary
The presence and isolation in a partially purified form of a substance from dog's liver which destroys secretin and has the characteristics of an enzyme are described; it is heat labile, does not dialyze, is most active in pH range 3-5 and shows an initial linear relationship of activity to increasing concentration and incubation time. It acts also on nonspecific substrates such as hemoglobin and casein. SIE was found also in dog's kidney. The enzyme may be a cathepsin and not a specific “secretinase.” Secretin is inactivated by plasmin at neutral pH; it is possible, as indicated by Rogers, that “secretinase” in blood might be identified with this enzyme.
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