Abstract
Summary
A single pituitary gland was transplanted adjacent to the mammary gland of the right inguinal region in intact and ovariectomized Strong A mice. Lobuloalveolar and duct development occurred locally around the pituitary graft in intact hosts while duct growth and minimal endbud development were observed in the glandular tissue adjacent to the graft in ovariectomized hosts. These data indicate that the ovary is necessary for the maximal response of mammary tissue to the direct, local effect of a pituitary isograft in Strong A mice.
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