Abstract
Summary
Young adult male rats exposed to a single dose of 450 r or 900 r total body x-irradiation exhibited a highly significant reduction 1, 3 and 6 days post x-irradiation in the serotonin concentration of the blood, spleen, brain and small intestines. No significant reduction in tissue serotonin levels occurred in rats exposed to 900 r total body x-irradiation and administered 2-mercapto-ethylguanidine intraperitoneally at a level of 200 mg per kg of body weight 20 minutes prior to x-irradiation exposure, paired the binding of serotonin not only to platelets but to various tissues as well has not, however, been excluded.
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