Effect of Phenylephrine on Responses of the Rabbit Aortic Strip to Isoproterenol. ∗

Abstract

Summary

1. Simultaneous addition of 1-phenylephrine (PE) and 1-isoproterenol (ISU) to the rabbit aortic strip significantly augmented contractions above the mere additive responses produced by each drug alone. 2. Addition of atropine to the bath fluid permitted an increase of ISU dose range which, together with PE, produced such augmented contractions. 3. The findings are correlated with ISU vasomotor reversal in the whole animal.

I am indebted to Dr. Theodore Koppanyi for his interest and encouragement.