Erythropoietic Stimulating Factor (ESF) as a Stimulant of Tumor Growth. ∗

Abstract

Summary

Four experimental procedures have been tested for ability to increase ESF concentrations (as measured by Fe⁵⁹ uptake) and increase tumor growth. It was concluded that ESF extracts prepared by a modified method of Borsook or the method of White and procedures which increase endogenous ESF production (partial hepatectomy and cobalt chloride administration) are capable of stimulating Novikoff hepatoma growth in rats.