Abstract
Summary
Amphotericin B was shown to have a high order of in vitroactivity against T. congolense, whereas only limited activity was observed in vivo. The limited activity was attributed to the rapid phagocytosis of amphotericin B by cells of the reticuloendothelial system (RES) with resulting lowered concentration free in the blood stream. Marked potentiation of activity was observed when intravenous treatment with amphotericin B was preceded by the blockade of the cells of the reticuloendothelial system (RES) with suitable agents such as thorium dioxide or triamcinolone acetonide.
Get full access to this article
View all access options for this article.