Abstract
Summary
The absorption and hydrolysis of aspirin has been examined under various experimental conditions. Aspirin appears to be absorbed intact from the gastrointestinal tract. High concentrations of acetylsalicylate in the plasma can be demonstrated following oral ingestion of soluble but not insoluble aspirin preparations. This is correlated with the increased rate of absorption of the soluble products. There appears to be a rapid hydrolysis of acetylsalicylate in vivo and it is suggested that the principal site of this hydrolysis is the tissues. Direct evidence for hydrolysis of acetylsalicylate to salicylate by the liver of the dog has been demonstrated.
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