Abstract
Summary
The hypothalamic regulation of FSH secretion has been studied in the unilaterally ovariectomized androgen-sterilized female rat. Comparable degreees of ovarian hypertrophy were observed in sterile and normal cyclic rats. Destruction of the anterior hypothalamus of the sterile rat markedly curtailed the release of FSH from the adenohypophysis. These data suggest not only that discrete FSH and LH centers exist in the hypothalamus of the rat but also that the syndrome of persistent-estrus results more likely from an imbalance in LH rather than in FSH secretion.
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