Abstract
Summary
Growth hormone, methyl testosterone or stilbestrol, when given alone or in combination were not able to counteract the inhibitory effects of 6-methyl prednisolone on body weight gain and collagen synthesis at the site of subcutaneously implanted poly-vinyl sponges. This experiment emphasizes the importance of dosage, since at lower concentration (0.2 mg/day) growth hormone had been found to be of benefit in this respect. The rate of uptake of radioglycine by skin collagen was depressed by the hormonal administration and the only significant increase of protein synthesis among the tissues investigated occurred at the perineal muscle of the androgen treated rats. This again points to the unique behavior of the muscles of the perineal complex and to its unsuitability for serving as an estimate of anabolic non-androgenic activity.
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