Abstract
Summary
The anabolic steroid methan-drostenolone partially antagonized the growth inhibiting effects of glucocorticoids in rats and also, depending on the type of experiment, augmented or added to the anti-inflammatory activity of these steroids. Similar activity was found with methyltestosterone and testosterone, whereas norethandrolone and progesterone were inactive. The action of methandrostenolone was independent of the adrenal. Methandrostenolone itself showed no other signs of glucocorticoid-like activity.
The authors wish to express their appreciation to Dr. Robert Gaunt for advice and encouragement and to Mrs. Hanna Sylwestrowicz for statistical evaluation. Thanks are due also to Nancy Howie, Margot Stein, Patricia Reilly and Viola Dube for technical assistance.
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