Abstract
Summary
Evidence is presented to show that 16α-hydroxylation or 16α, 17α-ketalization of cortisone produces a profound loss in thymolytic activity. In contrast to the 11-hydroxylated analogue, formation of the 16α, 17α-acetonide of Δ1, 16α-hydroxy-9α-fluoro-cortisone does not potentiate biological activity.
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