Abstract
Summary
Vaccination with viable or heat-killed oral anaerobic gram negative cocci (genus Veillonella) increased the resistance of a strain of Swiss-Webster mice to the lethal effects of veillonella endotoxin. Protection was best conferred with serologically specific endotoxin prepared from the strain of veillonella used for vaccination. Utilizing weight loss to sublethal dosages as a measure of biological effects of endotoxin, the duration and extent of weight loss in vaccinated mice is also considerably reduced as compared to nonvaccinated animals. Vaccination with heat-killed veillonellae significantly protected B. pertussis-sensitized mice against veillonella endotoxin, but not against lethal doses of E. coli endotoxin, histamine, or serotonin.
Vaccination of mice with another oral gram negative bacterium (Fusobacterium) did not protect pertussis-sensitized mice against the lethal effect of veillonella endotoxin.
Get full access to this article
View all access options for this article.