Abstract
Summary
Results of this study indicate that heparin can inhibit the lethal effects of Russell's Viper venom in a dose-response manner. This protective activity was also demonstrated with other sulfated mucopolysaccharides of the connective tissue and with sulfated polysaccharides of exogenous origin. Heparin, however, proved to be the most potent substance tested.
The possibility that the secretion of heparin from mast cells is an important factor in natural resistance to this venom has been discussed.
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