Abstract
Summary
Urinary excretion of 5-hydroxyindole compounds before and after 5-hy-droxytryptophan infusion was studied in paralysis agitans and a control group of other neurological disorders. The findings appear to rule out a systemic defect of serotonin metabolism associated with basal ganglia dysfunction in these patients. However, a localized biochemical or physiological lesion within the central nervous system involving 5-hydroxyindoles remains a speculative possibility.
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