Abstract
Summary
The passive transfer of large numbers of homologous lymphoid cells presensitized to recipient tissues into normal adult mice was capable of inducing runt disease. The recipient mice showed the characteristic clinical and pathologic sequelae described in this condition when induced in immunologically incompetent hosts. Severity of the disease was influenced by number and strain of transferred cells. A strain cells elicited a more intense clinical and pathological reaction against their CBA hosts than was seen in the A host transfused with CBA cells. During the period of runting, homologous skin grafts of the opposite strain were tolerated far beyond the usual rejection time of untreated homografted A and CBA mice.
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