Abstract
Summary
Four transplantable human tumors (H. Ep. 3, H.S. 1, . Ad. 1 and A-42) were gorwn on the CAM of chick embryos and used to determine the anti-tumor potential of hadacidin. In testing samples of hadacidin, there was consistent anti-tumor activity. When a comparison among the tumor types of their response to hadacidin was made, A-42 appeared to be consistently more sensitive to hadacidin than were the other types of tumors. Using two different routes of administration, intraperitoneal and per os, hadacidin inhibited the growth of H.S. 1 in the x-irradiated and cortisone treated rat. The positive results obtained in the mammalian host are further indications of the antitumor potentials of hadacidin.
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