Note on the effect of animal extracts upon the secretion of the pancreas

Abstract

Our experiments were made upon etherized cats who were killed before regaining consciousness. A Bernard cannula was inserted into the pancreatic duct inside the lumen of the intestine. The biliary duct was previously ligated. We then injected secretin solution into the jugular, as no secretion was noted before its injection. We then counted, after the injection of secretin, the number of drops falling every 5 minutes for three periods. Then we injected the same amount of secretin plus a watery solution of one of the dried glands. Then we counted for three periods the number of drops every 5 minutes. Finally we again injected the same amount of secretin solution and again noted the number of drops every 5 minutes for three periods. If in the second period we obtained a marked increase over or decrease below the first period and third period, we inferred that the animal extract had some action. We obtained the following results. We also have inserted their effects upon the volume of the gland for comparison.

These experiments were performed before the recent judicial decision in Pennsylvania upon experimentation.