Abstract
In two cases of nephritis of the uremic type with high nonprotein nitrogen and urea, very high figures for both uric acid and creatinine have been observed. The increase in the concentration of these substances is best shown in tabular form. The figures are in mgm. per 100 c.c. of blood.
The progressive increase in the various constituents as the condition approaches a fatal termination is well shown in Case 2. Attention is called to the possible etiological importance of the retention of creatinine on account of its containing the toxic guanidine group, also to the probable diagnostic and prognostic value of the determinations for uric acid and creatinine in this condition. The possible etiological bearing of the retention of creatinine is being considered from the standpoint of experimental nephritis.
Estimations of total solids, total nitrogen, chlorides, sugar, and cholesterol have been made in all our cases in addition to the above determinations. In our earlier estimations of creatinine, Shaffer's suggestions for the estimation of creatinine in dilute solutions were followed, but recently we have employed Folin's new method which has been found very satisfactory.
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