The specific dynamic action of levulose,glycocoll and alanin in phlorhizin glycosuria

Abstract

Ingestion of levulose by a dog which has been phlorhizinized does not increase the metabolism; the respiratory quotient is not changed and levulose is converted into dextrose, for this alone appears in the urine and in increased quantity. Ingestion of glycocoll or alanin largely increases the metabolism in glycosuria, although they are not oxidized and are converted into glucose and urea. The conclusion is drawn that the preliminary cleavage products of carbohydrate break-down are not stimulants of metabolism, but that the increased heat production following carbohydrate ingestion is due to the mass action of sugar molecules. On the contrary, amino-acids or the oxy-or keto-acids produced from them act as stimuli upon the cells thereby increasing the heat production.