Experimental Cholelithiasis in the Guinea Pig. ∗

Abstract

Summary

Within 1 day after intravenous injection of C¹⁴-labeled Klebsiella polysaccharide, cholesterol and pigment precipitate and small firm masses appeared in the gall bladder bile of guinea pigs. No C¹⁴ was present in the precipitate and less than 1% of the label from the injected bacterial polysaccharide was excreted in the bile during the first 12 hours. Since bacterial polysaccharide could not be identified in the bile, the precipitate was not due to the direct physicochemical effect of this material. The label in bile underwent a single enterohepatic cycle and some of this label was conjugated with bile acids.