Abstract
Summary
Several synthetic 18-hydroxy-lated steroids lacking oxygen at carbon 11 were tested for mineralocorticoid properties in acute studies using adrenalectomized rats. A multiple dose assay with DCA described relative potencies of 4, 8 and 5% parenterally for 18-OH-DCA by the criteria of Na retention, K loss and reduction of the Na/K ratio in the urine. Approximately the same order of potency was found for the alcohol derivative, 18-OH-DOC. 18-OH-Progesterone was ineffective as a mineralocorticoid. No significant anti-mineralocorticoid activity was found with 18-OH-progesterone or 18-OH-DCA.
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