Abstract
Summary
Equilibrium dialysis experiments with pooled sera of rats demonstrate that the binding activity of the specific corticosteroid-binding protein (“transcortin”) is higher in adrenalectomized and hypophysectomized animals than in normal controls. Rat serum at both 4°C and 37°C has a higher binding affinity for corticosterone than for Cortisol, whereas in human serum at 4°C, Cortisol appears to be bound more firmly than corticosterone. The “transcortin” systems of man and rat, therefore, show distinct differences.
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