Abstract
Summary
The levels of di- and triphosphopyridine nucleotides have been studied in rat liver after fasting and during oxidation of ethanol. The changes in diphosphopyridine nucleotides have also been studied in baker's yeast during ethanol oxidation. By fasting alone a slight decrease of DPN/DPNH ratio mainly due to a fall in the concentration of DPN is noted. Total DPX + DPNH is also decreased slightly. When the animals are metabolizing ethanol the DPN/DPNH ratio decreases further, due to an increase of DPNH, and especially in the fasted animals a fairly marked increase of the total DPN + DPNH can be noted. Similar changes are observed in baker's yeast during ethanol oxidation. Triphosphopyridine nucleotide is mainly present in the liver in its reduced form, and the TPN/TPNH does not change significantly during ethanol oxidation.
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