Abstract
Summary
The free 17 hydroxycorticosteroid concentrations of gastric juice were determined in 6 normal and 3 incompletely hypophysectomized dogs and compared with urine and blood levels under control conditions and following stimulation with corticotropin or cortisone. Concentration of 17 hydroxycorticosteroid in stomach aspirates was about one-third as great as blood and one-fifth as large as urine concentrations in these animals. In 6 normal dogs steroid concentrations were considerably elevated in blood and urine and only slightly increased in gastric juice in response to corticotropin or cortisone. The urine steroid values failed to rise upon stimulation in 2 of the 3 partially hypo-physectomized dogs, but the response in blood and gastric juice was comparable to the normals. The gastric juice of 3 normal dogs during the control period was analyzed chromatographically and a steroid with mobility characteristics similar to tetrahydrocortisol was found. It appears that the stomach may serve as a supplemental excretory organ for 17 hydroxycorticosteroid catabolites.
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