Abstract
Summary
In vitro studies with guinea pig monocytes showed that vaccination of the donor with formalin-killed Brucella abortus, failed to result in development of certain cellular properties that are typical for phagocytes obtained from donors that are immune by virtue of innate resistance or prior infection. That is, while brucellae fail to undergo intracellular multiplication in monocytes from immune donors, they do multiply in monocytes from donors treated with killed vaccine, even though the extent of such multiplication was found to be less than in monocytes from normal, susceptible donors. An attempt has been made to relate this finding to the problem of effective immunization against a pathogen like brucella, which presumably requires an effective alteration of both humoral and cellular factors.
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