Abstract
Summary
The effects of single and multiple doses of Cortisol on liver phosphorylase activity have been determined and correlated with alterations in blood glucose and liver glycogen. Phosphorylase activity was increased 12 hours after a single injection of Cortisol and continued to rise for 48 hours. Multiple injections of the hormone produced a much greater increase in enzyme activity than did a single dose. Elevation of blood sugar and liver glycogen which followed Cortisol occurred several hours before a change in phosphorylase activity could be demonstrated.
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