Abstract
Summary
Calcium and magnesium binding by oxytetracycline, observed spectropho-tometrically, occurs in a step-wise fashion. A variant of Job's principle applies to these reactions. The log Kca 2 OTC was found to be 3.0 and the log KCa 2 OTC 2.0. The log KMgOTC equaled 3.6; while log KMg 2 OTC was 2.4. Still higher metal to ligand complexes may exist, but the 1:1 and 2:1 oxytetracycline complexes are postulated to be the chief molecular species occurring in vivo.
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